Do you think
you’re allergic to alcohol? Don’t worry, you’re not alone. We recently hosted a
round table discussion about Alcohol Allergies, and we wanted to write a
follow up blog post on this topic to share with those researching the topic on
line. However, because there are many different alcohol allergens found in
liquors, wines and beers, we are going to break this topic down into a few
different posts.
Let’s first
understand the differences between alcohol allergies and alcohol intolerance.
Reactions to
alcohol, whether true alcohol allergies or just intolerances, are some of the
most common complaints we get at Hudson Allergy. Determining if it’s
a true allergy is really the first step, because this can be life-threatening.
An allergic reaction is typically felt shortly after consuming whatever you’re
allergic to. Symptoms can include wheezing, abdominal pain, cramping, hives, difficulty
swallowing, and throat swelling. In severe cases it can even be fatal.
Many
people have reactions to alcohol that are NOT true allergies. These symptoms
include facial flushing, nasal congestion and headache. This can be due to an
inherited defect in a protein that normally breaks down alcohol. Alcohol is
seen by the body as a toxin, and the body has two proteins that are turned on
to help break the alcohol down into something more benign.
One of the
proteins is called ADH1B, which breaks the alcohol down into a chemical called
acetaldehyde. This chemical is more toxic than alcohol, and needs to be
broken down further by a second enzyme. In some people, their ADH1B works so
well that the body turns alcohol into acetaldehyde faster than the second
enzyme can break it down. That causes a buildup of the acetaldehyde in the
blood. Acetaldehyde then causes the symptoms of flushing, headache
and nasal congestion. Although not imminently dangerous like an
allergic reaction, people with this intolerance to alcohol have a higher risk
of esophageal and liver cancer if they continue to drink.
True
allergies to alcohol are different than intolerances. Instead of reacting to
the buildup of a small molecule like acetaldehyde, truly allergic people react
to very large proteins. Each of the three main types of alcoholic
beverages (wine, beer and hard liquor or spirits) can present with
different types of allergies.
If you are
interested in reading about specific allergies that are triggered by beer, wine
or spirits, please read the following blog posts. Cheers!